Decreased Phosphate

A reduction in serum phosphate concentration below the lower limit of normal (<2.5 mg/dL or 0.8 mmol/L), which may impair energy metabolism, 2,3-DPG and ATP generation, and contribute to neuromuscular, cardiac, and hematologic dysfunction.

Causes

• Shift of phosphate into cells

  • Severe malnutrition

  • Refeeding syndrome

  • Respiratory alkalosis

• Decreased intestinal absorption

  • Vitamin D deficiency

  • Diarrhea

  • Vomiting

  • Crohn's disease

  • Phosphate-binding antacids

• Renal phosphate loss

  • Hyperparathyroidism

  • Alcohol abuse

  • Diuretics