Elevated CSF protein

An abnormal increase in total cerebrospinal fluid protein concentration above the reference range (typically >45-60 mg/dL), indicating disruption of the blood-brain or blood-CSF barrier and/or intrathecal protein synthesis in central nervous system pathology. Possible causes are infections (meningitis, encephalitis, neurosyphilis), Guillain-Barré syndrome, multiple sclerosis, brain tumor, CNS trauma, brain hemorrhage, Froin's syndrome, and diabetes.

An abnormal increase in total cerebrospinal fluid (CSF) protein concentration above the reference range (typically >45-60 mg/dL), reflecting disruption of the blood–brain barrier or blood–CSF barrier, impaired CSF flow, or increased intrathecal protein synthesis due to central nervous system pathology.

Causes

• Central nervous system infections

  • Meningitis

  • Encephalitis

  • Neurosyphilis

• Guillain–Barré syndrome

• Multiple sclerosis

• Brain tumor

• CNS trauma

• Intracranial hemorrhage: Subarachnoid hemorrhage

• CSF flow obstruction: Froin's syndrome

• Diabetes mellitus

• Spinal cord compression

• Inflammatory radiculopathies