Elevated IgA

An increased serum immunoglobulin A (IgA) concentration above the age- and assay-specific reference range (adults 18-50 years: approximately 0.7-3.7 g/L), reflecting enhanced mucosal or systemic immune activation, chronic antigenic stimulation, or monoclonal immunoglobulin production.

Causes

• Chronic infections

  • HIV infection

  • Hepatitis B infection

  • Hepatitis C infection

  • Parasitic infections

• Liver disease

  • Chronic hepatitis

  • Cirrhosis

  • Alcohol-related liver disease

• Autoimmune and inflammatory disorders

  • Rheumatoid arthritis

  • Systemic lupus erythematosus (SLE)

  • Celiac disease

  • Crohn's disease

  • Ulcerative colitis

• Plasma cell disorders

  • IgA multiple myeloma

  • Other IgA monoclonal gammopathies

• Chronic lung diseases with immune stimulation