Hyperosmolality

Abnormally high concentration of osmotically active solutes (glucose, sodium, and urea) in body fluids (normal range for serum: 275-295 mOsm/kg). Possible causes are severe dehydration/hypernatremia, uremia, infections, medications (corticosteroids, thiazide diuretics, atypical antipsychotics, β-blockers), or marked hyperglycemia with or without ketoacidosis.