Non-necrotizing granuloma

A cluster of epithelioid histiocytes, multinucleated giant cells, and surrounding lymphocytic inflammation without central necrosis, reflecting a chronic granulomatous immune response to persistent antigenic stimulation.

Causes

• Chronic bacterial infections

  • Atypical mycobacterial infections

  • Cat-scratch disease

  • Syphilis

• Fungal infections

  • Histoplasmosis

  • Blastomycosis

  • Coccidioidomycosis

• Foreign-body causing persistent tissue irritation

  • Surgical sutures

  • Splinters

  • Tattoo ink

  • Dust particles

  • Metals

• Autoimmune and inflammatory causes

  • Sarcoidosis

  • Crohn's disease

  • Rheumatoid arthritis

• Medications causing granulomatous reactions

  • NSAIDs

  • Antibiotics

• Granulomatous reactions after trauma or tissue injury