Pancreatic atrophy

A reduction in pancreatic parenchymal volume characterized by loss of acinar tissue, relative preservation or loss of islets, and replacement by fibrotic and/or fatty tissue, typically secondary to chronic pancreatitis, autoimmune pancreatitis, obstruction of the pancreatic duct, metabolic syndrome, cystic fibrosis, previous pancreatic surgery, and medications (immune checkpoint inhibitors).