Pancreatic necrosis

An irreversible ischemic necrosis of pancreatic parenchyma, often with peripancreatic fat necrosis, typically occurring as a severe complication of acute pancreatitis and predisposing to infection, systemic inflammatory response, organ failure, and local collections requiring debridement. Possible causes are gallstones, alcohol abuse, abdominal trauma, hypertriglyceridemia, hypercalcemia, medications (diuretics, antibiotics, chemotherapy), pancreatic tumor, and cystic fibrosis.