Decreased Renin

A reduction of plasma renin activity or direct renin concentration below the reference range, indicating suppression of renin–angiotensin–aldosterone system activity and often associated with low-renin forms of hypertension.

Plasma Renin Activity:

• Supine: 0.2 - 1.6 ng/mL/hr

• Upright: 0.5 - 4.0 ng/mL/hr

Direct Renin Concentration (varies by age):

• Supine: 3.0 - 42.0 pg/mL

• Upright: 4.0 - 60.0 pg/mL

Causes

• Endocrine disorders

  • Primary aldosteronism (Conn's syndrome)

  • Liddle syndrome

  • Gordon syndrome

• Kidney failure or reduced nephron mass

  • Hyporeninemic hypoaldosteronism

• Sodium or volume expansion

• Aging

• Medications

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

  • β-blockers

  • Renin inhibitors

  • Mineralocorticoid receptor blockers

  • High-dose corticosteroids