Disseminated Intravascular Coagulation

An acquired syndrome of systemic intravascular activation of coagulation leading to widespread microvascular thrombosis with consumption of platelets and coagulation factors, causing secondary bleeding and potential multiorgan dysfunction or failure.

Causes

• Sepsis

• Trauma

• Malignancy

• Placental abruption

• Amniotic fluid embolism

• Pre-eclampsia

• Anaphylaxis

• Toxic snake venom reactions