Elevated Aldolase

An increase in aldolase concentration above the upper limit of normal (adults: 1.0-7.5 U/L, children: <14.5 U/L), indicating increased release of this enzyme from damaged skeletal muscle or liver tissue.

Causes

• Inflammatory muscle diseases

  • Polymyositis

  • Dermatomyositis

• Muscular dystrophies

  • Duchenne muscular dystrophy

  • Limb-girdle muscular dystrophy

• Skeletal muscle injury

  • Rhabdomyolysis

  • Burns

  • Trauma

  • Strenuous exercise

• Cardiac muscle injury

  • Myocardial infarction

• Liver disorders

  • Hepatocellular injury

  • Hepatitis

• Infections

  • Infectious mononucleosis

• Malignancy

  • Liver cancer

  • Pancreatic cancer

  • Prostate cancer