Elevated Methanol

An abnormally increased concentration of methanol in blood. May cause severe metabolic disturbances, including high anion gap metabolic acidosis, visual impairment (optic nerve toxicity), and central nervous system toxicity (coma).

• Normal range: ~0.03-0.25 mg/dL or 0.3-2.5 mg/L

• Toxic concentrations: >20 mg/dL or >200 mg/L

• Lethal concentrations: >200 mg/dL or >2000 mg/L

Causes

• Toxic exposure

  • Accidental ingestion of methanol-containing products

  • Intentional ingestion (suicide attempt)

  • Occupational exposure in industrial settings

• Methanol-containing substances

  • Windshield washer fluid

  • Industrial solvents

  • Fuel additives

  • Improperly produced alcoholic beverages (illicit or contaminated alcohol)