Elevated Progesterone

Serum progesterone concentration above the expected reference range for the patient's sex, age, and cycle or gestational phase (follicular phase: 0.1-1.5 ng/mL, luteal phase: 2.0-25.0 ng/mL, postmenopausal: <1.0 ng/mL, adult male: 0.2-0.9 ng/mL), typically reflecting luteal activity and potentially altering endometrial receptivity. Possible causes are physiological ovulation spike, exogenous progesterone (birth control, fertility treatment, hormone replacement therapy), luteal cysts, pregnancy, or, less commonly, congenital adrenal hyperplasia or ovarian neoplasia.

An increased serum progesterone concentration above the expected reference range for the patient's sex, age, and reproductive or gestational phase:

• Follicular phase: 0.1–1.5 ng/mL

• Luteal phase: 2.0–25.0 ng/mL

• Postmenopausal: <1.0 ng/mL

• Adult male: 0.2–0.9 ng/mL

Causes

• Physiological causes

  • Ovulation-related progesterone surge

  • Pregnancy

  • Increased luteal phase activity

• Medications and hormone therapy

  • Exogenous progesterone supplementation

  • Hormonal contraception

  • Fertility treatment

  • Hormone replacement therapy

• Ovarian disorders

  • Luteal cysts

  • Ovarian neoplasia

• Congenital adrenal hyperplasia