Hyperproteinemia

An abnormal elevation of total serum protein concentration above the normal reference range (>8.3 g/dL or >83 g/L), typically resulting from increased immunoglobulin production, increased acute-phase proteins, or reduced plasma water content.

Causes

• Dehydration --> hemoconcentration

• Inflammation and infection --> increased immunoglobulins

• Plasma cell and hematologic disorders --> increased immunoglobulin

  • Multiple myeloma

  • Monoclonal gammopathy of undetermined significance (MGUS)

  • Waldenström macroglobulinemia

  • Other plasma cell dyscrasias

• Amyloidosis (protein deposition)

• Kidney failure --> reduced clearance of immunoglobulins

• Liver failure: Cirrhosis --> increased immunoglobulin production