Liver failure

A severe deterioration or loss of hepatic function, resulting from extensive hepatocellular injury and impaired synthetic, detoxification, and metabolic capacity, often manifesting with coagulopathy, jaundice, encephalopathy, and multi-organ dysfunction. Possible causes for acute liver failure are drug toxicity (paracetamol), toxins (mushroom), viral hepatitis A/B/E, Budd-Chiari syndrome, acute fatty liver of pregnancy, and HELLP syndrome. Possible causes for chronic liver failure are alcohol abuse, viral hepatitis B/C, fatty liver disease, autoimmune diseases (PSC, PBC, AIH), and genetic disorders (hemochromatosis, Wilson's disease).