Natriuresis

Increased renal excretion of sodium in the urine.

Causes

• Endocrine and renal causes

  • Hypoaldosteronism

  • Primary adrenal insufficiency

  • Kidney failure affecting sodium reabsorption (salt-wasting nephropathy)

  • Recovery phase of acute kidney injury

• Cardiovascular causes

  • Heart failure: Atrial natriuretic peptide, Brain natriuretic peptide

  • Hypertension with pressure-related natriuresis

  • Volume expansion states

• Diuretics: Loop diuretics, Thiazide diuretics, Potassium-sparing diuretics

• Cerebral salt-wasting syndrome

• Syndrome of inappropriate antidiuretic hormone secretion (SIADH)

• Excessive dietary sodium intake with renal adaptation