Necrolytic migratory erythema

A distinctive, recurrent, erosive, and blistering annular erythematous dermatosis, typically involving intertriginous and periorificial areas, characterized histologically by superficial epidermal necrosis and psoriasiform epidermal hyperplasia.

Causes

• Glucagonoma

• Nutritional deficiency-related causes

  • Zinc deficiency

  • Amino acid deficiency

  • Essential fatty acid deficiency

  • Severe malnutrition secondary to increased glucagon activity

• Liver failure affecting nutrient metabolism

• Gastrointestinal disease causing intestinal malabsorption

  • Celiac disease

  • Inflammatory bowel disease

  • Chronic pancreatitis

• Severe systemic illness causing nutritional depletion

• Postoperative states affecting nutrient absorption