Osteoblastic bone lesion

Focal area of abnormally dense, hardened bone, caused by increased deposition of mineralized bone matrix due to excessive osteoblastic activity or impaired bone remodeling.

Causes

• Osteoblastic metastatic disease:

  • Prostate carcinoma

  • Breast cancer

  • Small cell lung cancer

  • Hodgkin lymphoma

  • Medulloblastoma

• Benign and reactive causes

  • Healing fracture

  • Bone remodeling after trauma

  • Osteomyelitis

  • Bone islands (enostosis)

  • Paget disease of bone

• Genetic and metabolic causes

  • Osteopetrosis

  • Other sclerosing bone dysplasias

  • Fluorosis-related bone sclerosis

• Chronic osteomyelitis

• Degenerative changes with reactive sclerosis

• Medication-related or treatment-induced bone sclerosis (rare)