TSH receptor antibodies

Autoantibodies directed against the thyroid-stimulating hormone (TSH) receptor. Elevated levels (typically >1.0-3.3 IU/L) support the diagnosis of autoimmune thyroid disease. Depending on their functional activity, they may stimulate or block the TSH receptor.

Associated conditions

• Hyperthyroidism: Graves' disease (TSH receptor-stimulating antibodies)

• Hypothyroidism

  • Hashimoto's thyroiditis (TSH receptor-blocking antibodies)

  • Atrophic autoimmune thyroiditis

• Neonatal thyroid dysfunction due to transplacental maternal TRAb