Coagulopathy

A disorder of hemostasis characterized by impaired blood coagulation, due to quantitative or qualitative abnormalities of clotting factors, platelets, or other components of the coagulation system, resulting in a predisposition to bleeding, thrombosis, or both.

Causes

• Hemophilia A or B

• Von Willebrand disease

• Liver disease

• Disseminated intravascular coagulation

• Vitamin K deficiency

• Sepsis

• Lupus anticoagulant

• Massive trauma (blood loss, hypothermia, acidosis)

• Medications (warfarin or heparin)

• Massive blood transfusion