Elevated IgE

An increased serum immunoglobulin E (IgE) concentration above the age-adjusted reference range (adults: approximately 1.5–150 kU/L), reflecting increased IgE-mediated immune activation, most commonly due to allergic/atopic disease, parasitic infection, or immune dysregulation.

Causes

• IgE-mediated hypersensitivity and atopy

  • Asthma

  • Allergic rhinitis

  • Atopic dermatitis (eczema)

  • Food allergy

• Parasitic infections

  • Ascariasis

  • Hookworm infection

  • Other helminth infections

• Fungal and infectious disorders

  • Allergic bronchopulmonary aspergillosis

  • HIV infection

  • Tuberculosis

• Malignancy

  • Hodgkin lymphoma

  • IgE-producing multiple myeloma

• Immune disorders

  • Hyper-IgE syndrome (Job syndrome)

  • Primary immunodeficiency disorders

• Inflammatory bowel disease (Crohn's disease, ulcerative colitis)

• Cigarette smoking