Elevated Lipase

An increase in serum lipase concentration above the upper reference limit (~0-160 U/L), reflecting leakage of pancreatic digestive enzymes into the circulation and serving as a biochemical marker of pancreatic injury.

Causes

• Pancreatic disorders

  • Acute pancreatitis

  • Chronic pancreatitis

  • Pancreatic duct obstruction

  • Pancreatic tumors or other pancreatic injury

• Salivary gland inflammation (parotitis)

• Biliary and gastrointestinal disorders

  • Gallstones

  • Cholecystitis

  • Bowel obstruction

  • Peptic ulcer disease

• Metabolic and systemic disorders

  • Kidney failure (reduced clearance of lipase)

  • Hypertriglyceridemia

  • Diabetic ketoacidosis

• Medications and substances

  • Corticosteroids

  • Opioids

  • Birth control pills

  • Diuretics

  • Alcohol