Hypergammaglobulinemia

Increase in serum gamma globulins (normal range: 0.7-1.6 g/dL or 7-16% of total serum protein) due to excessive production of immunoglobulins by plasma cells. Typically associated with chronic inflammation (viral hepatitis, HIV, tuberculosis, mononucleosis), autoimmune disease (SLE, Rheumatoid Arthritis, and Sjögren's syndrome), liver pathology (cirrhosis, autoimmune hepatitis, alcohol-induced liver injury), or malignancy (leukemia or lymphoma).