Lytic bone lesion

Focal area of pathological bone resorption with decreased mineralized matrix, producing a radiolucent defect on imaging, typically due to osteoclastic overactivity. Possible causes are malignancy (osteosarcoma, chondrosarcoma, multiple myeloma, metastasis from lung, breast, kidney, thyroid, and prostate), benign lesions (bone cysts, fibrous dysplasia, enchondroma), infections (osteomyelitis, tuberculosis), and hyperparathyroidism.