Thrombocytopenia

TA hematologic disorder characterized by a persistently reduced circulating platelet count (<150 × 10⁹/L), predisposing to mucocutaneous and internal bleeding. Possible causes include impaired production (bone marrow cancer, bone marrow failure, chemotherapy, radiotherapy, toxic chemicals like benzene, nutritional deficiency of vitamin B12/folate/iron, alcohol abuse), increased destruction (autoimmune disease/ITP/lupus, medications/HIT, infections/HIV/sepsis, preeclampsia/HELLP syndrome, DIC, TTP), sequestration (splenomegaly), or dilution of platelets.