Hepatomegaly

An abnormal enlargement of the liver beyond normal dimensions, detectable clinically by physical examination or by imaging.

Causes

• Steatotic liver disease

• Cholestatic liver diseases

• Hepatitis (viral, autoimmune, or toxic)

• Infectious causes: Liver abscess, infectious mononucleosis

• Cardiovascular and vascular causes

  • Heart failure causing hepatic venous congestion

  • Budd-Chiari syndrome

  • Hepatic venous outflow obstruction

• Neoplastic and focal lesions

  • Liver cysts

  • Hemangioma

  • Hepatic adenoma

  • Hepatocellular carcinoma

  • Metastatic tumors

• Infiltrative and storage disorders: Amyloidosis, hemochromatosis

• Drug-induced liver injury